منابع مشابه
Pharmacogenetic guidance: individualized medicine promotes enhanced pain outcomes
The use of pharmacogenomics has become more prevalent over the past several years in treating many disease states. Several cytochrome P450 enzymes play a role in the metabolism of many pain medications including opioids and antidepressants. Noncytochrome P450 enzymes such as methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) also play a role in the explanation ...
متن کاملIndividualized medicine 2010
Molecular and cell biology have revolutionized not only diagnosis, therapy and prevention of human diseases but also greatly contributed to the understanding of their pathogenesis. Based on modern molecular and biochemical methods it is possible to identify on the one hand point mutations and single nucleotide polymorphisms. On the other hand, using high throughput array technologies, it is pos...
متن کاملGenetic variation and individualized medicine.
Mansell is with the Health, Physical Education, and Recreation Dept, Lincoln University, Lincoln University, PA. Tierney is with the Dept of Kinesiology, and Krynetskiy and Mishra, the School of Pharmacy, Temple University, Philadelphia, PA. Driban is with the Division of Rheumatology, Tufts Medical Center, Boston, MA. Clegg is with the Dept of Athletics, George Washington University, Washingto...
متن کاملPharmacogenetics, pharmacogenomics, and individualized medicine.
Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. The convergence of pharmacogenetics ...
متن کاملFrom Individualized Treatment of Sickle Cell Pain to Precision Medicine: A 40-Year Journey.
In the 1970s, sickle cell pain was treated with trial and error approach by increasing or decreasing the dose of an opioid or switching from one analgesic to another. This approach was controversial with criticism and doubt about its usefulness. Since then, advances in determining the structure of opioid receptors and the role of the CYP450 enzymes in metabolizing opioids revealed that these an...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Therapeutic Strategies
سال: 2009
ISSN: 1740-6773
DOI: 10.1016/j.ddstr.2010.10.001